How does your cat respond to being picked up?

One of my cats loves being picked up, although she is a nervous type and doesn't stick around if we don't put her down in just the right place. The other cat is completely moody. Sometimes she loves it, and will jump in the bed with us at night, but I'd say around 50% of the time she wants nothing to do with it. She won't fight it if we pick her up, but as soon as we put her down she'll go calmly back to whatever it was she was doing.