My sister has an old cat that gets angry and hiss at people, when extended family come to visit at holidays and birthday celebrations, etc. We wondered why because when she had friends over, her cat stays calm and doesn't mind her friends visiting. Well, we found out that our brother teases her cat when no one is looking. So, we, as extended family, often all come at once to her house and so, her cat associates our brother's teasing with all the extended family visiting.
Now, my sister puts her cat in her bedroom when extended family visit for the holidays, etc. Her cat is happy to get away from all the extended family. And our brother doesn't have an opportunity to tease. Well, at least not our sister's cat.